About the study

The principal aim of this study is to evaluate the safety and tolerability of RO7049665 in participants with active ulcerative colitis.

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria

1. Diagnosed with Ulcerative Colitis (UC) for at least 12 weeks prior to screening
2. Screening colonoscopy for colorectal cancer conducted within the prior two years if a history of pancolitis with disease duration ≥ 8 years or history of left-sided colitis and disease duration ≥12 years
3. Evidence of disease activity at time of screening
4. Insufficient clinical response to standard of care (SOC) therapy or intolerance to SOC

Exclusion criteria

1. Diagnosis of Crohn's disease or indeterminate colitis
2. History of infection with hepatitis B, human immunodeficiency virus (HIV), active hepatitis C virus (HCV) infection, or other chronic infection
3. Active infections requiring systemic therapy with antibiotic, antiviral or antifungal or febrile illness within 7 days before Day -1
4. History of primary or acquired immunodeficiency

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.