About the study

The purpose of this study is to assess the safety, tolerability and preliminary effectiveness of CC-92480 (BMS-986348) in novel therapeutic combinations for the treatment of Relapsed or Refractory Multiple Myeloma (RRMM).

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria

1. Relapsed or refractory multiple myeloma (MM) and must:
2. have documented disease progression during or after their last myeloma therapy
3. be refractory to, intolerant to, or not a candidate for available, established therapies known to provide clinical benefit in MM
4. Must have measurable disease
5. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1
6. Agree to follow the CC-92480 Pregnancy Prevention Plan (PPP)

Exclusion criteria

1. Known active or history of central nervous system (CNS) involvement of MM
2. Plasma cell leukemia; Waldenstrom's macroglobulinemia; polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome; or clinically significant light-chain amyloidosis.
3. Impaired cardiac function or clinically significant cardiac disease
4. Previous SARS-CoV-2 infection within 14 days for asymptomatic or mild symptomatic infections or 28 days for severe/critical illness prior to Cycle 1 Day 1 (C1D1)
5. For Part 1: received prior therapy with CC-92480
6. For Part 2: received prior therapy with CC-92480, tazemetostat, BMS-986158, or trametinib
7. Previously received allogeneic stem-cell transplant at any time or received autologous stem-cell transplant within 12 weeks of initiating study treatment
8. Received any of the following within 14 days prior to initiating study treatment:
9. Plasmapheresis
10. Major surgery
11. Radiation therapy other than local therapy for myeloma associated bone lesions
12. Use of any systemic anti-myeloma drug therapy
13. Used any investigational agents within 28 days or 5 half-lives (whichever is shorter) prior to initiating study treatment
14. COVID-19 vaccine within 14 days prior to C1D1 Other protocol-defined inclusion/exclusion criteria apply

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.