About the study

The design of a phase I, open-label, dose finding study was chosen in order to establish a safe and tolerated dose of single agent WVT078 alone and in combination with WHG626 in patients relapses and/or refractory Multiple Myeloma (MM)

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria

1. Subjects who are relapsed and/or refractory to two or more regimens including an IMID, proteasome inhibitor, and an anti-CD38 agent (if available)

Exclusion criteria

1. Use of systemic chronic steroid therapy (>or= 10mg/day prednisone or equivalent) or any immunosuppressive therapy within 7 days of first dose of study treatment
2. Malignant disease other than being treated on this study
3. Active known or suspected autoimmune disease
4. Impaired cardiac function or clinically significant cardiac disease
5. Treatment with cytotoxic or small molecule antineoplastics or any experimental therapy within 14 days or 5 half-lives whichever is shorter
6. Active central nervous system involvement by malignancy or presence of symptomatic CNS metasteses

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.