About the study

This is a phase Ib/II open label study. The escalation part will characterize the safety and tolerability of JDQ443 single agent and JDQ443 in combination with the other study treatments (TNO155 and tislelizumab) in advanced solid tumor patients. After the determination of the maximum tolerated dose / recommended dose for a particular treatment arm, dose expansion will assess the anti-tumor activity and further assess the safety, tolerability, and PK/PD of each regimen at the maximum tolerated dose / recommended dose.

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria

1. Adult patients with advanced (metastatic or unresectable) KRAS G12C mutant solid tumors who have received standard of care or are intolerant or ineligible to approved therapies
2. ECOG Performance Status of 0 or 1
3. At least one measurable lesion as defined by RECIST 1.1
4. Prior treatment with a KRAS G12C inhibitor may be allowed for dose escalations of combinations and a subset of groups in dose expansion

Exclusion criteria

1. Tumors harboring driver mutations that have approved targeted therapies, with the exception of KRAS G12C mutations
2. Symptomatic brain metastases or known leptomeningeal disease
3. Clinically significant cardiac disease or risk factors at screening
4. A medical condition that results in increased photosensitivity Other protocol-defined inclusion/exclusion criteria may apply.

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.