About the study

Image-guided tumor ablation is a non-surgical, minimally invasive therapy available for local therapy of some carcinomas as an alternative to surgical treatment. This study assesses whether cryoablation can be used as an alternative to surgery in cases of early invasive breast carcinoma.

Who can take part?

You may be eligible to participate in the study if you meet the following criteria:

Inclusion criteria

1. Unifocal primary invasive breast carcinoma
2. Pathological report should be complete (with the result of ER, PR , HER2, KI67 and FISH report of ERBB2 gene if necessary)
3. Maximum tumor size ≤2.5 cm in its greatest diameter
4. Ultrasound visible lesion

Exclusion criteria

1. Multifocal or multicentric invasive breast carcinoma
2. Ductal carcinoma in-situ
3. Breast cancer with skin involvement
4. Clinically positive axilla (N1, N2 or N3)
5. Distance from lesion and skin less than 5 mm
6. Prior neoadjuvant systemic therapy for breast cancer
7. Distant metastasis

For a full list of inclusion/exclusion criteria, please visit ClinicalTrials.gov

Study locations

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How to apply

Determine if a study site for this clinical trial is near you. Contact the study to apply.